https://wiki.biodiversity.cern.ac.cn/index.php?action=history&feed=atom&title=%E8%8C%83%E8%A1%A1%E5%AE%87 2026-05-14T19:23:22Z 本wiki上该页面的版本历史 MediaWiki 1.40.0 https://wiki.biodiversity.cern.ac.cn/index.php?title=%E8%8C%83%E8%A1%A1%E5%AE%87&diff=30348&oldid=prev 2025-09-23T17:13:01Z

<p>导入1个版本</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <tr class="diff-title" lang="zh-Hans-CN"> <td colspan="1" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td> <td colspan="1" style="background-color: #fff; color: #202122; text-align: center;">2025年9月23日 (二) 17:13的版本</td> </tr><tr><td colspan="2" class="diff-notice" lang="zh-Hans-CN"><div class="mw-diff-empty">（没有差异）</div> </td></tr></table>

Zhouyi https://wiki.biodiversity.cern.ac.cn/index.php?title=%E8%8C%83%E8%A1%A1%E5%AE%87&diff=30347&oldid=prev 2025-09-23T17:09:41Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="zh-Hans-CN"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2025年9月23日 (二) 17:09的版本</td> </tr> <!-- diff cache key biodiversity:diff::1.12:old-29966:rev-30347 --> </table>

meta>Unknown user https://wiki.biodiversity.cern.ac.cn/index.php?title=%E8%8C%83%E8%A1%A1%E5%AE%87&diff=29966&oldid=prev 2025-09-23T14:38:58Z

<p>导入1个版本</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <tr class="diff-title" lang="zh-Hans-CN"> <td colspan="1" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td> <td colspan="1" style="background-color: #fff; color: #202122; text-align: center;">2025年9月23日 (二) 14:38的版本</td> </tr><tr><td colspan="2" class="diff-notice" lang="zh-Hans-CN"><div class="mw-diff-empty">（没有差异）</div> </td></tr></table>

Zhouyi https://wiki.biodiversity.cern.ac.cn/index.php?title=%E8%8C%83%E8%A1%A1%E5%AE%87&diff=29965&oldid=prev 2025-09-23T14:33:34Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="zh-Hans-CN"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2025年9月23日 (二) 14:33的版本</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">第1行：</td> <td colspan="2" class="diff-lineno">第1行：</td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== '''性别''' ==</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">男</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== '''工作单位''' ==</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">浙江大学</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== '''职称/职务''' ==</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">研究员</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== '''主要研究方向''' ==</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">主要研究哺乳动物卵巢功能的分子调节机理以及卵巢相关疾病的发生机理</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== '''工作年限（从事该领域研究的起始时间）''' ==</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">15年（起始：2010）</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== &#039;&#039;&#039;主要研究成果&#039;&#039;&#039; ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== &#039;&#039;&#039;主要研究成果&#039;&#039;&#039; ==</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">1）早期研究集中在蛋白激酶在哺乳动物卵母细胞减数分裂和受精中的作用。利用小鼠、大鼠和猪卵母细胞为实验模型，提出蛋白激酶C亚型调节卵皮质颗粒释放，Polo</del>-like激酶和钙调蛋白依赖的蛋白激酶参与调节卵母细胞减数分裂，促性腺激素通过激活MAPK诱导卵母细胞减数分裂成熟。相关文章在Biology of Reproduction, Cell Cycle, Experimental Cell Research等国际主流期刊上发表，并获得中国科学院院长优秀奖和中国科学院动物研究所优秀研究生等荣誉。</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">（1）早期研究集中在蛋白激酶在哺乳动物卵母细胞减数分裂和受精中的作用。利用小鼠、大鼠和猪卵母细胞为实验模型，提出蛋白激酶C亚型调节卵皮质颗粒释放，Polo</ins>-like激酶和钙调蛋白依赖的蛋白激酶参与调节卵母细胞减数分裂，促性腺激素通过激活MAPK诱导卵母细胞减数分裂成熟。相关文章在Biology of Reproduction, Cell Cycle, Experimental Cell Research等国际主流期刊上发表，并获得中国科学院院长优秀奖和中国科学院动物研究所优秀研究生等荣誉。</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>（2）最早克隆了模式生物非洲爪蟾的Separase基因，并研究了该基因在减数分裂染色体分离过程中的作用，以及细胞周期过程中Separase蛋白酶活性的调节机制。</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>（2）最早克隆了模式生物非洲爪蟾的Separase基因，并研究了该基因在减数分裂染色体分离过程中的作用，以及细胞周期过程中Separase蛋白酶活性的调节机制。</div></td></tr> </table>

meta>Unknown user https://wiki.biodiversity.cern.ac.cn/index.php?title=%E8%8C%83%E8%A1%A1%E5%AE%87&diff=27840&oldid=prev 2025-09-16T19:02:35Z

<p>导入1个版本</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <tr class="diff-title" lang="zh-Hans-CN"> <td colspan="1" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td> <td colspan="1" style="background-color: #fff; color: #202122; text-align: center;">2025年9月16日 (二) 19:02的版本</td> </tr><tr><td colspan="2" class="diff-notice" lang="zh-Hans-CN"><div class="mw-diff-empty">（没有差异）</div> </td></tr></table>

Zhouyi https://wiki.biodiversity.cern.ac.cn/index.php?title=%E8%8C%83%E8%A1%A1%E5%AE%87&diff=27839&oldid=prev 2025-09-16T19:01:22Z

<p></p> <p><b>新页面</b></p><div><br /> == &#039;&#039;&#039;主要研究成果&#039;&#039;&#039; ==<br /> <br /> <br /> 1）早期研究集中在蛋白激酶在哺乳动物卵母细胞减数分裂和受精中的作用。利用小鼠、大鼠和猪卵母细胞为实验模型，提出蛋白激酶C亚型调节卵皮质颗粒释放，Polo-like激酶和钙调蛋白依赖的蛋白激酶参与调节卵母细胞减数分裂，促性腺激素通过激活MAPK诱导卵母细胞减数分裂成熟。相关文章在Biology of Reproduction, Cell Cycle, Experimental Cell Research等国际主流期刊上发表，并获得中国科学院院长优秀奖和中国科学院动物研究所优秀研究生等荣誉。<br /> <br /> （2）最早克隆了模式生物非洲爪蟾的Separase基因，并研究了该基因在减数分裂染色体分离过程中的作用，以及细胞周期过程中Separase蛋白酶活性的调节机制。<br /> <br /> （3）近年来，建立了卵巢颗粒细胞特异性的基因敲除小鼠模型，并成功应用该技术研究了多个重要信号转导分子和癌基因在卵巢中的功能。发现促性腺激素通过激活小G蛋白RAS和蛋白激酶ERK1/2，诱导卵母细胞成熟、排卵和黄体形成。用基因芯片技术筛选出小鼠基因组中所有受促性腺激素和ERK1/2调节的排卵相关基因，并用条件基因敲除技术证明C/EBP beta是卵巢颗粒细胞中重要的ERK1/2下游靶基因。通过这些研究，建立了促性腺激素诱导排卵的关键信号转导网络和基因表达谱。<br /> <br /> （4）在卵巢癌相关基因的研究中，发现抑癌基因PETN在调节卵泡生长、卵泡闭锁、排卵数目和黄体细胞寿命等方面具有重要作用。发现癌基因KrasG12D 诱导卵泡发育异常，导致雌性动物生殖力下降，发生卵巢早衰。建立了卵巢颗粒细胞癌和浆液性卵巢上皮细胞癌的小鼠模型，发现了PTEN和KrasG12D在诱导卵巢上皮细胞癌中的重要作用。<br /> <br /> <br /> <br /> [[分类:人员]]<br /> [[分类:研究人员]]<br /> [[分类:生物多样性保护专家]]<br /> <br /> </div>

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