王海滨

性别

男

工作单位

厦门大学

职称/职务

教授

主要研究方向

囊胚激活的分子机制，子宫内膜接受态建立和蜕膜化的分子调控网络

工作年限（从事该领域研究的起始时间）

9年（起始：2016）

论文著作

研究组已在J Clin Invest、Cell Res、PNAS、Nat Commun等刊物发表论文130多篇。

1.Tang Y, Qiu J, Tang Z, Li G, Gu M, Wang Y, Bao H, Deng W, Lu Z, Otsu K, Wang Z*, Wang H*, Kong S*. P38α MAPK is a gatekeeper of uterine progesterone responsiveness at peri-implantation via Ube3c-mediated PGR degradation. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2206000119.

2.Liu M, Deng W, Tang L, Liu M, Bao H, Guo C, Zhang C, Lu J, Wang H*, Lu Z*, Kong S*. Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling. Nat Commun. 2022 Feb 22;13(1):1006.

3.Huang P, Deng W, Bao H, Lin Z, Liu M, Wu J, Zhou X, Qiao M, Yang Y, Cai H, Rao F, Chen J, Chen D, Lu J, Wang H*, Qin A*, Kong S*. SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization. Elife. 2022 Mar 4;11:e72073.

4.Cheng J, Liang J, Li Y, Gao X, Ji M, Liu M, Tian Y, Feng G, Deng W, Wang H*, Kong S*, Lu Z*. Shp2 in uterine stromal cells critically regulates on time embryo implantation and stromal decidualization by multiple pathways during early pregnancy. PLoS Genet. 2022 Jan 13;18(1):e1010018.

5.Du L, Deng W, Zeng S, Xu P, Huang L, Liang Y, Wang Y, Xu H, Tang J, Bi S, Zhang L, Li Y, Ren L, Lin L, Deng W, Liu M, Chen J, Wang H*, Chen D*. Single-cell transcriptome analysis reveals defective decidua stromal niche attributes to recurrent spontaneous abortion. Cell Prolif. 2021 Nov;54(11):e13125.

6.Zhou C, Lv M, Wang P, Guo C, Ni Z, Bao H, Tang Y, Cai H, Lu J, Deng W, Yang X, Xia G, Wang H*, Wang C*, Kong S*. Sequential activation of uterine epithelial IGF1R by stromal IGF1 and embryonic IGF2 directs normal uterine preparation for embryo implantation. J Mol Cell Biol. 2021 Dec 6;13(9):646-661.

7.Bao H, Sun Y, Yang N, Deng N, Ni Z, Tang Y, Li G, Du L, Wang YL, Chen D, Wang H*, Kong S*. Uterine Notch2 facilitates pregnancy recognition and corpus luteum maintenance via upregulating decidual Prl8a2. PLoS Genet. 2021 Aug 30;17(8):e1009786.

8.Bao H, Liu D, Xu Y, Sun Y, Mu C, Yu Y, Wang C, Han Q, Liu S, Cai H, Liu F, Kong S, Deng W, Cao B, Wang H*, Wang Q*, Lu J*. Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2. BMC Biol. 2020 Oct 27;18(1):151.

9.He B, Zhang H, Wang J, Liu M, Sun Y, Guo C, Lu J, Wang H*, Kong S*. Blastocyst activation engenders transcriptome reprogram affecting X-chromosome reactivation and inflammatory trigger of implantation. Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16621-16630.

10.Kong S, Zhou C, Bao H, Ni Z, Liu M, He B, Huang L, Sun Y, Wang H*, Lu J*. Epigenetic control of embryo-uterine crosstalk at peri-implantation. Cell Mol Life Sci. 2019 Dec;76(24):4813-4828.

11.Lu J, Wu W, Xin Q, Zhou C, Wang J, Ni Z, Liu D, Xu Y, Yu Y, Yang N, Sun Y, He B, Kong S, Wang S*, Wang C*, Wang H*. Spatiotemporal coordination of trophoblast and allantoic Rbpj signaling directs normal placental morphogenesis. Cell Death Dis. 2019 Jun 5;10(6):438.

12.Xin Q, Kong S, Yan J, Qiu J, He B, Zhou C, Ni Z, Bao H, Huang L, Lu J, Xia G, Liu X*, Chen Z*, Wang C*, Wang H*. Polycomb subunit BMI1 determines uterine progesterone responsiveness essential for normal embryo implantation. J Clin Invest. 2018 Jan 2;128(1):175-189.

13.Cui T, He B, Kong S, Zhou C, Zhang H, Ni Z, Bao H, Qiu J, Xin Q, Reinberg D, Lydon JP, Lu J*, Wang H*. PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice. Cell Death Differ. 2017 Dec;24(12):2013-2021.

14.Ran H, Kong S, Zhang S, Cheng J, Zhou C, He B, Xin Q, Lydon JP, DeMayo FJ, Feng GS, Xia G, Lu Z*, Wang C*, Wang H*. Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase. Proc Natl Acad Sci U S A. 114(18):4816-4821, 2017.

15.Tu Z, Wang Q, Cui T, Wang J, Ran H, Bao H, Lu J, Wang B, Lydon JP, DeMayo F, Zhang S, Kong S*, Wu X*, Wang H*. Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice. Cell Death Differ. 23(1):169-81, 2016.

16.Liao Y, Jiang Y, He H, Ni H, Tu Z, Zhang S, Wang B, Lou J, Quan S*, Wang H*. NEDD8-mediated neddylation is required for human endometrial stromal proliferation and decidualization. Hum Reprod. 2015 May 23.

17.Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang HM, Wang YL, Li B, Chen Q*, Duan E*, Wang H*. Uterine Rbpj is required for embryo-uterine orientation and decidual remodeling via Notch pathway- independent and -dependent mechanisms. Cell Res., 24(8):925-42, 2014.

18.Lu J, Zhang S, Nakano H, Simmons DG, Wang S, Kong S, Wang Q, Shen L, Tu Z, Wang W, Wang B, Wang HM, Wang Y, van Es JH, Clevers H, Leone G, Cross JC*, Wang H*. A positive feedback loop involving gcm1 and fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 11(4):e1001536, 2013.

19.Zhang S, Lin H, Kong S, Wang S, Wang HM, Wang H*, Armant DR*. Physiological and molecular determinants of embryo implantation. Mol Aspects Med. doi:pii: S0098-2997(12)00158-6, 2013.

20.Lim H & Wang H. Uterine disorders and pregnancy complications: insights from mouse models. J CIin Invest. 120(4), 1004-15, 2010.