王磊

性别

男

工作单位

复旦大学

职称/职务

教授

主要研究方向

生殖遗传学。重点关注人类卵子、受精及早期胚胎发育的生理与病理机制

工作年限（从事该领域研究的起始时间）

8年（起始：2017）

代表论文

1.Wu T, Dong J, Fu J, Kuang Y, Chen B, Gu H, Luo Y, Gu R, Zhang M, Li W, Dong X, Sun X*, Sang Q*, Wang L*.The mechanism of acentrosomal spindle assembly in human oocytes. Science. 2022 Nov 18; 378(6621): eabq7361.

2.Sang Q, Ray PF, Wang L*.Understanding the genetics of human infertility. Science. 2023 Apr 14;380(6641):158-163.

3.Wang W, Miyamoto Y, Chen B, Shi J, Diao F, Zheng W, Li Q, Yu L, Li L, Xu Y, Wu L, Mao X, Fu J, Li B, Yan Z, Shi R, Xue X, Mu J, Zhang Z, Wu T, Zhao L, Wang W, Zhou Z, Dong J, Li Q, Jin L, He L, Sun X, Lin G, Kuang Y*, Wang L* and Sang Q*.Karyopherin α deficiency contributes to human preimplantation embryo arrest. J Clin Invest. 2023 Jan 17;133(2):e159951.

4.Li Q, Zhao L, Zeng Y, Kuang Y, Guan Y, Chen B, Xu S, Tang B, Wu L, Mao X, ; Sun X, Shi J, Xu P, Diao F, Xue S, Bao S, Meng Q, Yuan P, Wang W, Ma N, Song D, Xu B, Dong J, Mu J, Zhang Z, Fan H, Gu H, Li Q, He L, Jin L, Wang L*, Sang Q*, Large-scale analysis of de novo mutations identifies risk genes for female infertility characterized by oocyte and early embryo defects. Genome Biol. 2023 Apr 06;24(68).

5.Wang L*, Sang Q*. MOS is a novel genetic marker for human early embryonic arrest and fragmentation. EMBO Mol Med. 2021 Dec 7;13(12):e15323.

6.Qu R, Dong L, Zhang J, Yu X*, Wang L*, Zhu S*. Cryo-EM structure of human heptameric Pannexin 1 channel. Cell Res. 2020 Mar;30(5):446-448.

7.Zhang Z, Li B, Fu J, Li R, Diao F, Li C, Chen B, Du J, Zhou Z, Mu J, Yan Z, Wu L, Liu S, Wang W, Zhao L, Dong J, He L, Liang X, Kuang Y, Sun X, Sang Q*, Wang L*. Bi-allelic missense pathogenic variants in TRIP13 cause female infertility characterized by oocyte maturation arrest. Am J Hum Genet. 2020 Jul 2;107(1):15-23.

8.Zhao L, Xue S, Yao Z, Shi J, Chen B, Wu L, Sun L, Xu Y, Yan Z, Li B, Mao X, Fu J, Zhang Z, Mu J, Wang W, Du J, Liu S, Dong J, Wang W, Li Q, He L, Jin L, Liang X, Kuang Y, Sun X, Wang L*, Sang Q*. Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development. Protein Cell. 2020 Dec;11(12):921-927.

9.Sang Q*, Zhang Z, Shi J, Sun X, Li B, Yan Z, Xue S, Ai A, Lyu Q, Li W, Zhang J, Wu L, Mao X, Chen B, Mu J, Li Q, Du J, Sun Q, Jin L, He L, Zhu S, Kuang Y*, Wang L*. A pannexin 1 channelopathy causes human oocyte death. Sci Transl Med. 2019 Mar 27;11(485): eaav8731.

10.Sang Q*, Li B, Kuang Y, Wang X, Zhang Z, Chen B, Wu L, Lyu Q, Fu Y, Yan Z, Mao X, Xu Y, Mu J, Li Q, Jin L, He L, Wang L*. Homozygous mutations in WEE2 cause fertilization failure and female infertility. Am J Hum Genet. 2018 Apr 5;102(4):649-657.

11.Chen B, Zhang Z, Sun X, Kuang Y, Mao X, Wang X, Yan Z, Li B, Xu Y, Yu M, Fu J, Mu J, Zhou Z, Li Q, Jin L, He L, Sang Q*, Wang L*. Biallelic mutations in PATL2 cause female infertility characterized by oocyte maturation arrest. Am J Hum Genet. 2017 Oct 5;101(4):609-615.

12.Feng R, Sang Q, Kuang Y, Sun X, Yan Z, Zhang S, Shi J, Tian G, Luchniak A, Fukuda Y, Li B, Yu M, Chen J, Xu Y, Guo L, Qu R, Wang X, Sun Z, Liu M, Shi H, Wang H, Feng Y, Shao R, Chai R, Li Q, Xing Q, Zhang R, Nogales E, Jin L, He L, Gupta ML Jr, Cowan NJ*, Wang L*. Mutations in TUBB8 and human oocyte meiotic arrest. N Engl J Med. 2016 Jan 21;374(3):223-32.

13.Xu Y, Shi Y, Fu J, Yu M, Feng R, Sang Q, Liang B, Chen B, Qu R, Li B, Yan Z, Mao X, Kuang Y, Jin L, He L, Sun X*, Wang L*. Mutations in PADI6 cause female infertility characterized by early embryonic arrest. Am J Hum Genet. 2016, Sep 1;99(3):744-52.