王震波

性别

男

工作单位

中国科学院动物研究所

职称/职务

研究员

主要研究方向

受精机制，.生育力维持与重塑

工作年限（从事该领域研究的起始时间）

13年（起始：2012）

代表论著

Sun SM, Zhao BW, Li YY, Liu HY, Xu YH, Yang XM, Guo JN, Ouyang YC, Weng CJ#, Guan YC#, Sun QY#, Wang ZB#(2024). Loss of UBE2S causes meiosis I arrest with normal spindle assembly checkpoint dynamics in mouse oocytes. Development. Mar 15; 151(6): dev 202285.

Wang L, Liu C, Li L, Wei H, Wei W, Zhou Q, Chen Y, Meng TG, Jiao R, Wang ZB#, Sun QY#, Li W# (2024). RNF20 Regulates Oocyte Meiotic Spindle Assembly by Recruiting TPM3 to Centromeres and Spindle Poles. Adv Sci (Weinh). Jan 19:e2306986.

Lei WL, Du Z, Meng TG, Su R, Li YY, Liu W, Sun SM, Liu MY, Hou Y, Zhang CH, Gui Y, Schatten H, Han Z, Liu C, Sun F#, Wang ZB#, Qian WP#, Sun QY# (2023). SRSF2 is required for mRNA splicing during spermatogenesis. BMC Biol. Oct 23;21(1):231.

Liu SL, Zuo HY, Zhao BW, Guo JN, Liu WB, Lei WL, Li YY, Ouyang YC, Hou Y, Han ZM, Wang WZ#, Sun QY, # Wang ZB# (2023). A heterozygous ZP2 mutation causes zona pellucida defects and female infertility in mouse and human. iScience. Sep 4;26 (10): 107828.

Meng TG, Guo JN, Zhu L, Yin Y, Wang F, Han ZM, Lei L, Ma XS, Xue Y, Yue W, Nie XQ, Zhao ZH, Zhang HY, Sun SM, Ouyang YC, Hou Y, Schatten H, Ju Z, Ou XH#, Wang ZB#, Wong CC#L, Li Z#, Sun QY# (2023). NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition. Adv Sci (Weinh). Sep;10(27):e2301940.

Qiao JY, Zhou Q, Xu K, Yue W, Lei WL, Li YY, Gu LJ, Ouyang YC, Hou Y, Schatten H, Meng TG#, Wang ZB#, Sun QY# (2023). Mad2 is dispensable for accurate chromosome segregation but becomes essential when oocytes are subjected to environmental stress.Development. Jul 15;150(14):dev201398.

Zhang Q, Hao JX, Liu BW, Ouyang YC, Guo JN, Dong MZ, Wang ZB#, Gao F#, Yao YQ# (2022).Supplementation of mitochondria from endometrial mesenchymal stem cells improves oocyte quality in aged mice. Cell Prolif. Dec 8:e13372.

Liu W, Lu X, Zhao ZH, Su R, Li QL, Xue Y, Gao Z, Sun SS, Lei WL, Li L, An G, Liu H, Han Z, Ouyang YC, Hou Y, Wang ZB#, Sun QY#, Liu J# (2022).SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing. Elife. Nov 10;11:e78211.

Meng TG, Lei WL, Lu X, Liu XY, Ma XS, Nie XQ, Zhao ZH, Li QN, Huang L, Hou Y, Ouyang YC, Li L, Tang TS, Schatten H, Xie W, Gao SR, Ou XH#, Wang ZB#, Sun QY#（2022.Maternal EHMT2 is essential for homologous chromosome segregation by regulating Cyclin B3 transcription in oocyte meiosis. Int J Biol Sci. Jul 11;18(11):4513-4531.

Dong MZ, Ouyang YC, Gao SC, Ma XS, Hou Y, Schatten H, Wang ZB#, Sun QY#（2022）. PPP4C facilitates homologous recombination DNA repair by dephosphorylating PLK1 during early embryo development. Development. May 15;149(10):dev200351.

Zhu FY, Wang LL, Meng TG, Wang RL, Yang ZX, Cao Y, Zhu GY, Jin Z, Gao LL , Zeng WT, Wang ZB#, Sun QY#, Zhang D# (2021).Nature aging. 1(11):1-14.

Shen Y, Guo J, Zhang X, Wang X, Zhu S, Chen D, Xiong W, Lu G, Liu X, Dai C, Gong F, Wang Y#, Lin G#, Wang Z#, Xu W#(2022). Identification of a heterozygous variant of ZP2 as a novel cause of empty follicle syndrome in humans and mice. Hum Reprod. Feb 25:deac026.

Yue W, Wang Y, Meng TG, Zhang HY, Zhang XR, Ouyang YC, Hou Y, Schatten H, Wang ZB#, Sun QY#(2022). Kinetochore scaffold 1 regulates SAC function during mouse oocyte meiotic maturation. FASEB J.Mar;36(3):e22210

Lei WL, Li YY, Meng TG, Ning Y, Sun SM, Zhang CH, Gui Y, Wang ZB#, Qian WP#, Sun QY#(2021). Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis. Cell Death Dis.Sep 27;12(10):883.

Zhao BW, Sun SM, Xu K, Li YY, Lei WL, Li L, Liu SL, Ouyang YC, Sun QY#, Wang ZB#（2021）. FBXO34 Regulates the G2/M Transition and Anaphase Entry in Meiotic Oocytes. Front Cell Dev Biol. Mar 25;9:647103.

Meng TG*, Zhou Q*, Ma XS*, Liu XY*, Meng QR, Huang XJ, Liu HL, Lei WL, Zhao ZH, Ouyang YC, Hou Y, Schatten H, Ou XH#, Wang ZB#, Gao SR#, Sun QY#（2020）. PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome.Nat Commun. Dec 11;11(1):6354.

Zhao ZH, Meng TG, Li A, Schatten H, Wang ZB#, Sun QY#（2020）. RNA-Seq transcriptome reveals different molecular responses during human and mouse oocyte maturation and fertilization. BMC Genomics. Jul 10;21(1):475.

Zhou Q, Li J, Yue W, Li A, Meng TG, Lei WL, Fan LH, Ouyang YC, Schatten H, Wang ZB#, Sun QY# (2020). Cell division cycle 23 is required for mouse oocyte meiotic maturation. FASEB J. Jul;34(7):8990-9002.

Zhou Q, Meng QR, Meng TG, He QL, Zhao ZH, Li QN, Lei WL, Liu SZ, Schatten H, Wang ZB#, Sun QY#（2020）. Deletion of BAF250a affects oocyte epigenetic modifications and embryonic development. Mol Reprod Dev.May;87(5):550-564.

Meng TG, Lu X, Guo L, Hou GM, Ma XS, Li QN, Huang L, Fan LH, Zhao ZH, Ou XH, OuYang YC, Schatten H, Li L, Wang ZB#, Sun QY# (2019). Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation. FASEB J. Jan;33(1):1179-1187

Lei R, Bai X, Chang Y, Li J, Qin Y, Chen K, Gu W, Xia S, Zhang J, Wang Z#, Xing G#（2018）.Effects of Fullerenol Nanoparticles on Rat Oocyte Meiosis Resumption. Int J Mol Sci. Mar 1;19(3).

Yuan Y, Ma XS, Liang QX, Xu ZY, Huang L, Meng TG, Lin F, Schatten H, Wang ZB#, Sun QY# (2017). Geminin deletion in pre-meiotic DNA replication stage causes spermatogenesis defect and infertility. J Reprod Dev. Oct 18;63(5):481-488.

Meng TG, Hu MW, Ma XS, Huang L, Liang QX, Yuan Y, Hou Y, Wang H, Schatten H, Wang ZB#, Sun QY# (2017). Oocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice. Cell Death Dis. Jun 1;8(6):e2846.

Hu MW, Meng TG, Jiang ZZ, Dong MZ, Schatten H, Xu X, Wang ZB#, Sun QY# (2016). Protein Phosphatase 6 Protects Prophase I-Arrested Oocytes by Safeguarding Genomic Integrity. PLoS Genet. Dec 8;12(12):e1006513

Ma XS, Lin F, Wang ZW, Hu MW, Huang L, Meng TG, Jiang ZZ, Schatten H, Wang ZB#, Sun QY# (2016). Geminin Deletion in Mouse Oocytes Results in Impaired Embryo Development and Reduced Fertility. Mol Biol Cell. Mar 1;27(5):768-75.