熊敬维

性别

男

工作单位

北京大学

职称/职务

研究员

主要研究方向

系统研究心血管发育与心脏再生的基础和转化研究

工作年限（从事该领域研究的起始时间）

17年（起始：2008）

代表性论文

1. Wang C, Faloon PW, Tan Z, Lv Z, Zhang P, Ge Y, *Deng H, and *Xiong JW. (2007). Mouse Lycat controls the development of hematopoietic and endothelial lineages during in vitro ES cell differentiation. Blood, 110: 3601-3609.

2. *Xiong JW, Yu Q, Zhang J, and Mably JD. (2008). An acyltransferase controls the generation of hematopoietic and endothelial lineages in zebrafish. Circulation Research, 102:1057-1064.

3. Wang X, Yu Q, Wu Q, Bu Y, Chang NN, Yan S, Zhu X, and *Xiong JW. (2013). Genetic interaction between pku300 and fbn2b controls endocardial cell proliferation and valve development in zebrafish. Journal of Cell Science, 126:1381-91.

4. #Chang N, #Sun C, Gao L, Zhu D, Xu X, Zhu X, *Xiong JW, and *Xi J (2013). Genome Editing with RNA-guided Cas9 Nuclease in Zebrafish Embryos. Cell Research, 23:465-72.

5. *Hu XL, Chang N, Wang X, Zhou F, Zhou X, Zhu X and *Xiong JW (2013). Heritable gene targeting with gRNA/Cas9 in rats. Cell Research, 23: 1322-1325.

6. #Han P, #Zhou XH, Chang N, Xiao CL, Yan S, Ren H, Yang XZ, Zhang ML, Wu Q, Tang Y, Diao JP, Zhu X, Zhang CM, Li CY, *Cheng H, and *Xiong JW (2014). Hydrogen Peroxide Primes Heart Regeneration with a Derepression Mechanism. Cell Research, 24: 1091-1107.

7. Xiao CL#, Gao L#, Hou Y, Xu C, Chang N, Wang F, Hu K, He A, Luo, Y, Wang J, Peng JR, Tang F, Zhu X*, and Xiong JW*. (2016). Chromatin Remodeling Factor Brg1 Regulates Myocardial Proliferation and Regeneration in Zebrafish. Nature Communications, 7, 13787.

8. Lei L#, Yan SY#, Yang R, Chen JY, Li Y, Bu Y, Chang N, Zhou Q, Zhu X, Li CY*, and Xiong JW*. (2017). Spliceosomal Protein Eftud2 Mutation Leads to p53-dependent Apoptosis in Neuronal Progenitors in Zebrafish. Nucleic Acids Research, 45(6):3422-3436.

9. Yang R, Zhang Y, Huang D, Luo X, Zhang LR, Zhu X, Zhang XL, Liu Z*, Han J*, and Xiong JW*. (2017). Miconazole Protects Blood Vessels from MMP9-Dependent Rupture and Hemorrhage. Disease Models & Mechanisms, 10(3):337-348.

10. Pang MJ#, Bai L#, Zong W#, Wang X, Bu Y, Xiong C, Zheng J, Li J, Gao W, Feng Z, Chen LY, Zhang J, Cheng H, Zhu X*, and Xiong JW*. (2020). Light-Sheet Fluorescence Imaging Charts the Gastrula Origin of Vascular Endothelial Cells in Early Zebrafish Embryos. Cell Discovery, 6:74.

11. Du J#, Zheng L#, Gao P, Yang H, Yang WJ, Guo F, Liang R, Feng M, Wang Z, Zhang Z, Bai L, Bu Y, Xing S, Zheng W, Wang X, Quan L, Hu XL, Wu H, Chen Z, Chen, LY, Wei K, Zhang Z, Zhu X, Zhang XL, Tu Q, Zhao SM*, Lei X*, and Xiong JW*. (2022). A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration. Cell Stem Cell, 29:545-558.

12. Zhou X#, Zhang C#, Wu XY#, Hu X, Zhang Y, Wu XL, Zheng L, Gao P, Du JY, Zheng W, Shang H, Hu K, Jiang Z, Nie Y, Hu S, Xiao RP, Zhu X*, and Xiong JW*. (2022). Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in the acute inflammatory phase of myocardial infarction. Nature Communications 13(1):6672. doi: 10.1038/s41467-022-33631-z.