孙永华

简介

主要从事鱼类生殖细胞发育与前沿生物育种技术研究。揭示了若干调控鱼类生殖细胞发育和胚胎发育的关键因子及其作用机制；首创鱼类诱导性原始生殖细胞（iPGC）的新理论和新技术；首次实现鱼类基因编辑配子的借腹生殖（也称“借腹怀胎”）前沿育种技术的突破；受命从零开始建成了全球三大库之一的国家斑马鱼资源中心（http://zfish.cn），牵头完成“斑马鱼1号染色体全基因敲除计划”，相关成果入选国家“十三五”科技创新成就展。先后主持国家重点研发计划“发育编程及其代谢调节”重点专项等一批科研项目。在Advanced Science、Genome Research、Nature Communications、PLOS Biology、Development以及Cell Research、Science Bulletin、Science China-Life Sciences等国内外学术刊物上发表论文120余篇。相关论文入选Springer Nature年度亮点论文，被Faculty of 1000专门推荐，被国际知名学者专项Research 等。

代表性论文

1)    Chen, Z., He, M., Wang, H., Li, X., Qin, R., Ye, D., Zhai, X., Zhu, J., Zhang, Q., Hu, P., Sui, G., Sun, Y.* (2024). An intestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally-deposited yolk lipids. Nature Communications, 15, 9769. 10.1038/s41467-024-54258-2. 发现鱼类胚胎内源-外源营养转换调控的新机制

2)    Li, X., Liu, C., Zhang, R., Li, Y., Ye, D., Wang, H., He, M., and Sun, Y.* (2024). Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury. J Biol Chem, 107405. 10.1016/j.jbc.2024.107405. 发现内源合成DHA促进鱼类肝脏脂质稳态的新机制

3)    Wang, X., Zhu, J., Wang, H., Deng, W., Jiao, S., Wang, Y., He, M., Zhang, F., Liu, T., Hao, Y., Ye, D., Sun, Y.* (2023). Induced formation of primordial germ cells from zebrafish blastomeres by germplasm factors. Nature Communications 14, 7918. 10.1038/s41467-023-43587-3.（Research Highlight亮点推荐论文，“为鱼类生殖细胞诱导鸡尾酒干杯”）取得鱼类诱导性原始生殖细胞理论和技术的突破

4)    Zhang, R., Tu, Y.X., Ye, D., Gu, Z., Chen, Z.X.*, and Sun, Y.* (2022). A Germline-Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells. Advanced Science  9, e2203631. 10.1002/advs.202203631. （Back cover paper，背封面论文）揭示线粒体动态调控鱼类生殖干祖细胞发育的新机制

5)    He, M., Jiao, S., Zhang, R., Ye, D., Wang, H., and Sun, Y.* (2022). Translational control by maternal Nanog promotes oogenesis and early embryonic development. Development 149. 10.1242/dev.201213. (in companion with Research Highlight recommendation entitled “Nanog: not just a pluripotency factor”, 当期亮点论文)揭示母源Nanog通过全局性翻译控制促进鱼类卵质的新机制

6)    Zhang, F., Hao, Y., Li, X., Li, Y., Ye, D., Zhang, R., Wang, X., He, M., Wang, H., Zhu, Z., and Sun, Y.* (2022). Surrogate production of genome-edited sperm from a different subfamily by spermatogonial stem cell transplantation. Sci China Life Sci 65, 969-987.  首次实现亚科间鱼类基因编辑配子的借腹生殖

7)    He, M., Zhang, R., Jiao, S., Zhang, F., Ye, D., Wang, H., and Sun, Y.* (2020). Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors. PLOS Biology 18, e3000561. 揭示Nanog通过控制母源β-catenin活性保护早期胚胎发育的新机制

8)    Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., et al. (2020). Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome Research 30, 118–126. 实现斑马鱼1号染色体全基因的系统性敲除，入选国家十三五科技创新成就展

9)    Zhang, Q.#, Ye, D.#, Wang, H., Wang, Y., Hu, W., and Sun, Y.* (2020). Zebrafish cyp11c1 Knockout Reveals the Roles of 11-ketotestosterone and Cortisol in Sexual Development and Reproduction. Endocrinology 161, DOI:10.1210/endocr/bqaa048  （2020-2023连续高被引论文）揭示11-KT和皮质醇调控性别发育和生殖的新机制

10) Zhang, F., Li, X., He, M., Ye, D., Xiong, F., Amin, G., Zhu, Z., and Sun, Y.* (2020). Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted primordial germ cells. Journal of Genetics and Genomics 47, 37-47. (Faculty of 1000推荐论文)

11) Li, X., Zhang, F., Wu, N., Ye, D., Wang, Y., Zhang, X., Sun, Y.*, and Zhang, Y.-A*. (2020). A critical role of foxp3a-positive Treg cells in maintaining immune homeostasis in zebrafish testis development. Journal of Genetics and Genomics. 47, 37-47.（封面论文）

12) Ye, D., Zhu, L., Zhang, Q., Xiong, F., Wang, H., Wang, X., He, M., Zhu, Z., and Sun, Y.* (2019). Abundance of Early Embryonic Primordial Germ Cells Promotes Zebrafish Female Differentiation as Revealed by Lifetime Labeling of Germline. Mar Biotechnol (NY) 21, 217-228. (Springer Nature 2019年度亮点论文)

13) Ye, D., Wang, X., Wei, C., He, M., Wang, H., Wang, Y., Zhu, Z., and Sun, Y.* (2019). Marcksb plays a key role in the secretory pathway of zebrafish Bmp2b. PLOS Genetics 15, e1008306. 揭示Marckb调控形态发生素BMP分泌的新机制

14) Zhu, Z.Y., and Sun, Y.H. (2000). Embryonic and genetic manipulation in fish. Cell Research 10, 17-27.